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Porcine parainfluenza virus 1 (PPIV1) is a newly characterised porcine respiratory virus. Current experimental problem research in three-week-old nursery pigs didn’t trigger illness. Nonetheless, it stays unclear how genetic variations contribute to viral pathogenesis. To characterize the pathogenesis of various PPIV1 isolates, three-week-old nursery pigs had been challenged with both PPIV1 isolate USA/MN25890NS/2016 (MN16) or USA/IA84915LG/2017 (IA17). A human parainfluenza virus 1 (HPIV1) pressure C35 ATCC® VR-94™ was included to guage swine as a mannequin for human parainfluenza.
All viruses had been efficiently re-isolated from bronchoalveolar lavage fluid and detected by RT-qPCR at necropsy. Microscopic lung lesions had been extra extreme within the IA17 group in comparison with the non-challenged unfavorable management group whereas variations weren’t discovered between the MN16 and management teams. Immunohistochemistry staining in respiratory samples confirmed a constant development of upper ranges of PPIV1 sign within the IA17 group adopted by the MN16 group, and no PPIV1 sign noticed within the HPIV1 or management teams.
This research suggests potential pathogenesis variations between PPIV1 isolates. Moreover, these outcomes point out that HPIV1 is able to replicating in nursery pigs after experimental inoculation. Nonetheless, medical illness or gross lung lesions weren’t noticed in any of the problem teams.
Welch M, Krueger Okay, Zhang J, Neveau M, Piñeyro P, Magstadt D, Predominant R, Gauger P. Characterization of Two Porcine Parainfluenza Virus 1 Isolates and Human Parainfluenza Virus 1 An infection in Weaned Nursery Pigs. Veterinary Sciences. 2023; 10(1): 18. https://doi.org/10.3390/vetsci10010018
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